Cost of palifermin
WebPalifermin (Kepivance) is administered as 60 mcg/kg/day, administered as an intravenous bolus injection for 3 consecutive days before and 3 consecutive days after myelotoxic therapy for a total of 6 doses. ... (QOL) but also on healthcare costs. Despite this, currently, there is no clinically effective localized/pharmacological therapy ... WebMay 19, 2024 · In these settings, the incidence of severe oral mucositis, defined as World Health Organization (WHO) grade 3 and 4 (G3/4), is reported at 80–100%, with a …
Cost of palifermin
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WebPalifermin is a truncated human recombinant keratinocyte growth factor [1] produced in Escherichia coli. KGF stimulates the growth of cells that line the surface of the mouth and intestinal tract.[2] ... Palifermin costs approximately 5,000 euros per treatment for a 70 kg patient. Annual sales. The worldwide profits for years the 2008–2011 ... WebNov 29, 2016 · To assess the efficacy, toxicity, and potential cost benefit of palifermin in the prevention of chemotherapy- and radiation-induced mucositis. Data Sources: MEDLINE and PubMed database searches were conducted (1966–May 2006) using the following search terms: palifermin, human keratinocyte growth factor, fibroblast growth factor, …
WebMucositis is a significant driver of the health care cost by increasing emergency room visits, hospitalization, ... economic analysis based on this study demonstrated that the benefit of decreased mucositis may … WebComment: Palifermin should not be administered within 24 hr before, during infusion of, or within 24 hr after administration of antineoplastic agents. Coadministration of palifermin within 24 hr of chemotherapy resulted in increased severity …
WebMar 6, 2014 · Adjusting for inflation to 2010 rates, the average cost of palifermin administration was $17,409 (myeloma) and $29,221 (lymphoma), which translates to an additional cost of $5,511 (myeloma) and $13,792 (lymphoma) per day of PCA use (severe pain) avoided. From a patient perspective, reduction in a day of severe mucositis that …
WebFeb 20, 2009 · The estimated total cost per patient for a patient treated with palifermin was $73,938, versus $77,533 for patients treated with placebo. An increase in total cost was …
WebJan 31, 2024 · We compared the estimated total hospital costs (in 2005 United States dollars) incurred by patients who received palifermin in the clinical trial with those incurred by patients who received placebo. bulge in thigh muscle above the kneeWebObjective: To assess the efficacy, toxicity, and potential cost benefit of palifermin in the prevention of chemotherapy- and radiation-induced mucositis. Data sources: MEDLINE … bulge in tire sidewall under warrantyWebPalifermin is recommended for patients receiving autologous HSCT (autoHSCT) for a hematologic cancer that involves total-body irradiation (TBI) to decrease the frequency of … bulge in the stomachWebMar 9, 2024 · Palifermin reduces the incidence of severe mucositis, but the agent remains underused, according to researchers. ... The high cost and toxicity associated with … crv folding center tableWebDec 17, 2012 · Previous analysis of the pivotal phase III study with palifermin reduced, albeit not significantly the cost of care with mean savings of $3595 per patient in those patients who received palifermin ... crv folding mirrorsWebNov 16, 2004 · We estimated the expected impact of palifermin on the hospital costs of transplantation. Methods: We classified the 212 pts from the phase 3 trial by presence of downstream outcomes of oral mucositis (bacteremia, FN, TPN, intubation) and by the number of hospital days. The cost of hospital days was not collected in the clinical trial, … bulge in tire treadWebMar 1, 2013 · Hence, cost-effectiveness and the clinical benefits of palifermin among various conditioning regimens have also been debated. This article reviews the published literature on the efficacy of palifermin and makes evidence-based recommendations for the use of palifermin in the HSCT setting. crv fog lights