Methoxy-x04的用途

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August undefined, 2024

WebMethoxy-X04 C23H20O3 CID 16049314 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, … http://www.pibb.ac.cn/pibbcn/article/html/20240095

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WebMethoxy-X04, a derivative of Congo red and Chrysamine-G, is a brain-permeable fluorescent probe for amyloid-β (Aβ). 体外活性 In in vitro binding studies, compared with Chrysamine-G (Ki = 25.3 nM), Methoxy-X04 exhibited similar … WebMethoxy-X04 is a derivative of Congo Red (Cat. No. 2588) and Chrysamine G that acts as a fluorescent probe for the detection of amyloid self-assembly in vitro and in vivo. It stains … trinity lutheran school harford county

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WebMethoxy-X04 Purity >98% Description Fluorescent amyloid β stain. BBB permeable. Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides ( 1) Reviews References ( 3) Biological Data Solubility & Handling Storage instructions +4°C. Protect from light. Solubility overview Webメトキシ基（—き、methoxy group）とは、有機化学において構造式が CH 3 O- と表される1価の置換基。メチルオキシ基。アルコキシ基の一種。導入法. 塩基の存在下、ヒドロキシ基にヨードメタンや硫酸ジメチルなどのメチル化剤を反応させるとメトキシ基となる。 trinity lutheran school grand island ne

Methoxy-X04 Cas# 863918-78-9 - GlpBio

WebDPX. Methoxy-XO4 staining, slides with sections are rinsed in distilled water for 5 min, and put in the Methoxy-XO4 solution (3.3 mg Methoxy-XO4 in 100 ml 40% ethanol/60%distilled water at pH 10.00) for 10 min. Then the slides are rinsed quickly twice in distilled water and air dried, when dry they are coverslipped with DPX. 3. Results http://www.maokangbio.com/m/productView.action?id=11273 trinity lutheran school grand islandWebTO-PRO-3是一种优秀的细胞核和染色体复染剂，不能穿透活细胞，但能渗透进入具受损膜特征的死细胞，使其在细胞群内是一种有用的死细胞指示剂。. 这一基于羰花青结构的染料呈现远红外荧光，激发和发射波长分别为642/661nm。. TO-PRO-3的长波长荧光在组织自荧光 ... trinity lutheran school hilbert wi

"Web23 nov. 2010 · 从发展历程来看，最初是刚果红类衍生物，如14C．柯胺G能与AD病人B蛋白特异性结合…J，｜4C．甲氧基．x04与AB纤维有较高的亲合力，静脉注射后脑107中国心理卫生协会第五届学术研讨会摄取量高112】；以后发展了硫磺素类衍生物，如3H—BTA一1和C－6－OH—BTA—l（也称c—PIB）与AB蛋白的亲合力是柯胺G的 ... " - Methoxy-x04的用途

Methoxy-x04的用途

Methoxy-X04, Tocris Bioscience Fisher Scientific

Web23 mrt. 2015 · Methoxy-X04 is a derivate of Congo red, that specifically binds to amyloid deposits in post mortem tissue and in vivo and therefore provides a fluorescent label [ 15 ]. Mice were anesthetized by Isofluoran. Imaging sessions lasted for no longer than 60 min and laser power was kept below 50 mW to avoid phototoxic effects. WebMethoxy-X04 is a fluorescent amyloid β (Aβ) probe for the detection and quantification of plaques, tangles and cerebrovascular amyloid. Methoxy-X04 Displays high in vitro binding affinity (Ki = 26.8 nM); binds selectively to fibrillar β-sheet deposits. Methoxy-X04 is a derivative of Congo Red (Cat. No. 5167).

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Web14 jan. 2024 · This section describes how to label amyloid plaques with methoxy-X04 (MeX04), a blood–brain barrier-penetrating amyloid-beta (Aβ) dye. After MeX04 is intraperitoneally injected into Alzheimer’s disease (AD) transgenic mice, it enters the brain and binds to the surface of Aβ plaques. http://www.delta-f.com/details/76081

WebCA2906226A1 CA2906226A CA2906226A CA2906226A1 CA 2906226 A1 CA2906226 A1 CA 2906226A1 CA 2906226 A CA2906226 A CA 2906226A CA 2906226 A CA2906226 A CA 2906226A CA ... Web18 sep. 2016 · Longer-wavelength dyes Amyloid- plaquesβ Methoxy-X04 Kim et al. (2015) excitation ~900 nm, emission > 600 nmHeo et al. (2013) Vascular imaging Texas red -> Quantum dots Activated coagulation factor XIII (FXIIIa; A15), in a thromboembolic model of stroke. (Aswendt et al. 2014) Emission 692 nm Zhang et al. (2012) Stroke studies 8.

Web22 dec. 2011 · Resorufin preferentially binds CAA in aged Tg2576 brain sections.Paraformaldehyde-fixed brain sections prepared from 16-month-old Tg2576 transgenic mice (Tg) or littermate wild-type mice were co-stained with 1 μM resorufin (Res) and 2 μM methoxy-X34 (X34), followed by fluorescent microscopy (N = 6 … Web首先，研究人员通过Methoxy-X04标记AD模型小鼠脑中的Aβ斑块，随后通过原子力显微镜首次在小鼠脑切片中发现，Aβ斑块相关的脑组织（PATs）的机械硬度明显高于非Aβ斑块相关的脑组织（NPATs）。脑切片原子力显微镜测量示意图大量研究表明，细胞所处微环境中硬度的变化对于细胞功能的转变至关重要 [8]。此外，小胶质细胞作为中枢神经系统中最重要 …

Web11 nov. 2016 · Methoxy_X04 was injected 24 h before imaging intraperitoneally to visualize amyloid deposits at an excitation wavelength of 800 nm. Scale bar, 20 μm. ( a ) Methoxy_X04-stained Aβ plaque.

Web15 nov. 2024 · 在该研究中，研究者利用Methoxy-X04在体标记脑中Aβ淀粉样斑块并结合原子力显微镜技术，明确了新鲜活体脑片中Aβ淀粉样斑块相关组织的硬度显著高于非Aβ淀粉样斑块相关组织。细胞对硬度等机械力刺激的感知，通常需要机械敏感的离子通道蛋白 5 。 trinity lutheran school hicksvilleWebBlood-brain barrier permeable amyloid β fluorescent marker. Blue fluorophore. Derivative of Congo Red ( ab145645) and Chrysamine G. Selectively binds fibrillar β-sheet deposits with high affinity (K. i. = 26.8 nM). Detects plaques, tangles and cerebrovascular … trinity lutheran school hoyleton ilWebsections were briefly stained with methoxy-X04 (1 M), fol-lowed by extensive washing to visualize dense core amyloid pathology. Other sections were treated with an avidin/biotin blocking kit (Vector Laboratories, Burlingame, CA), followed by treatment with 5% normal goat serum in Tris-buffered salinecontaining0.5%Tween20(TBST)for20min.Sections trinity lutheran school hoskins neWebMethoxy-X04 is a brain-permeable fluorescent probe for amyloid-β (Aβ) to detect and quantify plaques, tangles, and cerebrovascular amyloid.1 It displays high in vitro binding affinity (Ki = 26.8 nM) for fibrillar β-sheet deposits and is used to image Aβ plaques in the brains of living APP/PS1 mice, a transgenic model of familial Alzheimer's disease.[1],[2] … trinity lutheran school janesville mnWeb13 nov. 2024 · 在该研究中，研究者利用Methoxy-X04在体标记脑中Aβ淀粉样斑块并结合原子力显微镜技术，明确了新鲜活体脑片中Aβ淀粉样斑块相关组织的硬度显著高于非Aβ淀粉样斑块相关组织。细胞对硬度等机械力刺激的感知，通常需要机械敏感的离子通道蛋白【5】。研究者分析了已有报道的几种机械力感知蛋白在小胶质细胞中的表达情况，发现其 … trinity lutheran school jeneraWebMethoxy-X04 is a blood-brain barrier (BBB) permeable fluorescent amyloid β marker which specifically binds to amyloid deposits in postmortem AD brain sections. It can be used to … trinity lutheran school janesvilleWebMethoxy-X04 is a fluorescent dye that crosses the blood-brain barrier and selectively binds to beta-pleated sheets found in dense core amyloid Aβ plaques. For research use only. … trinity lutheran school kalispell mt