Olig2 astrocyte
Web04. jun 2007. · TGF-β1 and conditioned medium derived from neuron-astrocyte cocultures (CM) decreased the number of cells expressing the precursor marker nestin and increased that expressing GFAP in cortical progenitor cultures. These events were impaired by addition of neutralizing antibodies against TGF-β1. Increase in the number of GFAP … Web22. okt 2008. · In addition, cortical Olig2 ablation results in a decrease in proliferation of reactive astrocytes in response to injury. Cell-type-specific mutagenesis indicates that Olig2 ablation in GFAP+ astrocytes and their precursors rather than in neuronal or oligodendroglial cells is responsible for the reduction of reactive astrocyte proliferation.
Olig2 astrocyte
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Web1 day ago · Markers of astrocyte precursors are not enriched in IDH-mutant gliomas. Our studies show that despite differences in clinical manifestation and genomic alterations, all IDH-mutant gliomas resemble early stages of oligodendrocyte lineage and are stalled in oligodendrocyte differentiation due to blocked myelination program. ... OLIG1, OLIG2 ... Web14. jan 2024. · Elevated BMP-2 levels are translated into a rapid increase in Id3 expression in adult NSPC subpopulations, specifically in Olig2+ C cells and Thbs4+ SVZ-born astrocytes. Id3 then heterodimerizes with the bHLH transcription factor E47 and releases E47-mediated repression of astrocyte-specific gene expression.
WebJan 2003 - Present. My current research covers two interrelated fields, namely the adult neurogenesis and cellular reprogramming for regenerative biology in the central nervous system. While the study of adult neurogenesis can teach us the mechanisms employed by the nervous system to respond in an adaptive way to a changing environment, our ... Web21. avg 2024. · However, the mouse WM astrocyte conditioned medium from the 2b4 ho 2b5 ho mutants significantly decreased the percentage of MBP-/Olig2-positive cells compared to mouse WM astrocyte conditioned medium from controls (F 2, 8 = 6.23, p = 0.023; post hoc Dunnett wt vs 2b4 ho 2b5 ho, p = 0.014) and mouse GM astrocyte …
Web01. jul 2012. · In cultures of neural stem cells, downregulation or cytoplasmic translocation of Olig2 has been shown to cause a switch from an oligodendrocyte to an astrocyte fate ( Setoguchi and Kondo, 2004; Fukuda et al., 2004 ). However, the role of Olig2 in regulating the fate of NG2 cells is not known. WebThe mechanisms underlying astrocyte heterogeneity in the developing mouse brain are poorly understood. The bHLH transcription factor Olig2 is essential for motoneuron and …
OPCs are a population of glial cells in the CNS which comprise about 5% of total cells and are the main proliferating cell type in the resting state of adult CNS [11]. In the adult CNS, OPCs can differentiate into myelinating oligodendrocytes and are usually characterized as NG2 proteoglycan expressing cells. … Pogledajte više Oligodendrocytes are myelinating cells that are differentiated from OPCs under the control of bHLH transcriptional factor Olig2 [17]. Besides OPCs, we also analyzed the … Pogledajte više After discovering remarkable Olig2 expression in astrocytes within some specific regions, we further investigated whether the Olig2 expression level in astrocytes is … Pogledajte više Neurons are electrically excitable cells that are the basic functional units of the CNS. Olig2 plays a crucial role in the generation of motor … Pogledajte više Astrocytes are resident glial cells in the CNS besides oligodendrocytes and microglia. We further investigated whether Olig2 expression can be detected in the astrocytes of adult CNS by performing co-immunostaining … Pogledajte više
WebLocomotor function after spinal cord injury (SCI) is critical for assessing recovery. Currently, available means to improve locomotor function include surgery, physical therapy rehabilitation and exoskeleton. Stem cell therapy with neural progenitor cells (NPCs) transplantation is a promising reparative strategy. Along this line, patient-specific induced … residual chlorine analyzerWebOlig2 has further been shown to be critical in the proliferation of malignant glioma in brain tumors (Ligon et al., 2007). ... Kofuji P et al. Astrocyte signaling gates long-term depression at corticostriatal synapses of the direct pathway J. Neurosci. 2024-06-15 [PMID: 32541069] protein in farm fresh eggsWebIt is thought to be a necessary factor for oligodendrocyte progenitor cell commitment to an oligodendrocyte fate, along with the related factor Olig2. Olig1-null mice brains show impaired oligodendrocyte differentiation, though compensatory increased Olig2 expression may decrease the phenotype severity. Target information from Dai et al., 2015.. protein in fat free milkWeb10. avg 2005. · A role for Olig2 in astrocyte differentiation. Olig2 expression has not been reported previously in forebrain astrocytes. It is not surprising, however, that this is the … protein in fish as foodWeb26. sep 2014. · In the central nervous system, demyelinating diseases, such as multiple sclerosis, result in devastating long-term neurologic damage, in part because of the lack of effective remyelination in the adult human brain. One model used to understand the mechanisms regulating remyelination is cuprizone-induced demyelination, which allows … residual chlorine in tap waterWeb14. feb 2024. · Here, during lineage-tracing studies of cells expressing Olig2 using Olig2 CreER; Rosa-CAG-LSL-eNpHR3.0-EYFP transgenic mice, we found Olig2-lineage … residual capacity examination reportWeb27. sep 2004. · Nuclear accumulation of OLIG2 blocks astrocyte differentiation. (a–c) Cos7 cells were transfected with either (a and b) FLAG-tagged OLIG2-w or (c) FLAG-tagged OLIG2–NES. (b) LMB was used to block active export from the nucleus. Transfected OLIG2 was detected with anti-FLAG antibody (green) and the cells were counterstained with PI … residual catheterization