Stemness in cancer

Author: hequ

August undefined, 2024

網頁2016年9月9日 · Increased expression of galectin-3 was detected in advanced stages, compared to stage 1 or 2 in ovarian cancer patients, suggesting that galectin-3 supports stemness of these cells. Based on these results, we suggest that targeting galectin-3 may be a potent approach for improving ovarian cancer therapy. 網頁In addition, ESJ inhibited the maintenance of stemness in GSCs by suppressing the expression of epidermal growth factor receptor (EGFR)/EGFR variant III (EGFRvIII) and Notch intracellular domain. Intriguingly, the observed ESJ-induced suppression also appeared to induce the proteasomal degradation of EGFR/EGFRvIII.

Editorial: Role of p53 in cell metabolism, ferroptosis, and stemness

網頁Abstract. The ability of cancers to grow indefinitely has fueled the idea that cancer and stem cells may have common underlying mechanisms. Detailed gene expression maps have … 網頁2024年4月4日 · Stemness of cancer cells is a key feature for cancer progression and in many cases the source of its survival [7–12]. Understanding the development and acquisition of resistance in cancer cells may therefore provide … avi toys

Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their …

網頁Instead, cancer cells are highly plastic in term of stemness and CSCs and non-CSCs can interconvert into each other depending on the microenvironment. This model predicts the existence of cancer cells ranging from a pure CSC phenotype to pure non-CSC phenotype and that survival of a single cell can originate a new tumor. 網頁2024年7月21日 · BackgroundCancer stem cells (CSCs) have been proven to influence drug resistance, recurrence, and metastasis in tumors. Our study aimed to identify stemness … 網頁2024年4月11日 · what: The authors confirmed that CAF-secreted STC1 promoted HCC stemness and provided evidence for an amplifying STC1-Notch1 axis in HCC stromal-tumor crosstalk. The previous research proved that the CAF-induced promotion of HCC stemness was weakened after Notch1 was inhibited ; thus, in this part, the authors focused the … avi totaal

Enhancers of mesenchymal stem cell stemness and therapeutic …

Stemness in Cancer: Stem Cells, Cancer Stem Cells, and …

網頁Graduate School of Medicine Dentistry and Pharmaceutical Sciences Medical School Academic Field of Medicine, Dentistry and Pharmaceutical Sciences 網頁Abstract. Cancer progression entails a gradual loss of a differentiated phenotype in parallel with the acquisition of stem cell-like features. Cancer de-differentiation and the … avi to talia kumin網頁2024年7月1日 · Neural stemness is suggested to be the ground state of tumorigenicity and pluripotent differentiation potential. However, the relationship between these cell properties is unclear. Here, by disrupting the neural regulatory network in … avi työsuojelu kuopio

"網頁a newly identified driver of breast cancer stemness and metastasis. Using protein structure modeling and interface prediction-guided mutagenesis, we demonstrate that membrane CD81 interacts with CD44 through their extracellular regions in promoting ... " - Stemness in cancer

Stemness in cancer

The stromal-tumor amplifying stc1-notch1 feedforward signal promotes the stemness …

網頁2024年4月30日 · Regulatory programs that control the function of stem cells are active in cancer and confer properties that promote progression and therapy resistance. However, … 網頁2024年4月5日 · Background Colorectal cancer (CRC) is a fatal malignant tumor with poor prognosis. Cancer stem cells (CSCs) can cause metastasis, recurrence and drug resistance in CRC. This research aimed to analyze stemness-related prognostic genes of …

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網頁2024年3月15日 · Objectives The promoting roles of cyclin dependent kinase 1 (CDK1) have been revealed in various tumors, however, its effects in the progression of cancer stem cells are still confusing. This work aims to explore the roles of CDK1 in regulating the stemness of lung cancer cells. Methods Online dataset analysis was performed to evaluate the … 網頁A further rapamycin derivative, temsirolimus, was shown to inhibit cancer stem cells by inhibiting their stemness and epithelial-mesenchymal transition [73], [74]. Research has led to the development of a new generation of mTOR inhibitors that block the downstream substrate of both mTOR complex 1 and 2 [75] , sapanisertib, or INK128; a small-molecule …

網頁2024年6月11日 · Mesenchymal and stemness traits are known to characterize cancer stemness cell, which is responsible for tumor metastasis and resistance to conventional … 網頁2024年10月29日 · Cancer stemness, referring to the stem cell (SC)-like phenotype of cancer cells, has been widely recognized as a vital player in different aspects of tumorigenesis [50, 51]. In general, cancer stemness increases along with tumor progression [ 51 ].

網頁網頁Abstact Accumulating lines of experimental evidence have revealed that hypoxia-inducible factors, HIF-1α and HIF-2α, are key regulators of the adaptation of cancer- and metastasis-initiating cells and their differentiated progenies to oxygen and nutrient deprivation ...

網頁2024年3月19日 · However, the mechanism underlying stemness reprogramming of breast cancer cells (BCs) by hypoxic TME remains largely unknown. In the present study, we illustrated that HIF-2α, but not HIF-1α, induces stemness in BCs under hypoxia through SOD2 linking ...

網頁2024年3月31日 · Cancer stemness, referring to the stem-cell-like phenotype of cancer cells, has been recognised to play important roles in different aspects of … avi turvasähköposti網頁N1 - Funding Information: This study was supported by National Cancer Institute R01 CA129040, RO1 CA100855, and RO1 CA100855-05S3 to RCS. The funder had no role in study design, data collection and analysis, decision to … avi työsuojeluilmoitus網頁2 小時前 · Accumulating evidence implicates the importance of other mechanisms, including regulating cancer cell metabolism, ferroptosis, and cell stemness to support p53's anti … avi tuchman網頁TY - JOUR T1 - Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through … avi työmaan ennakkoilmoitus網頁Description. An effective small molecule anticancer agent that prevents cancer stem cells (CSC) from renewing themselves. It also induces cell death of CSC and non-stem cells. Synonyms. 2-Acetylnaphtho [2,3-b]furan-4,9-dione; BBI608; Napabucasin. Properties. avi työsuojelutarkastus網頁Labarge, M.A. 2010: The Difficulty of Targeting Cancer Stem Cell Niches : Drugs that Target the Stemness Pathways Clinical Cancer Research 16(12): 3121-3129 Merchant, A.A.; Matsui, W. 2010: Targeting Hedgehog: a Cancer Stem Cell Pathway : Drugs that Target the Stemness Pathways Clinical Cancer Research 16(12): 3130-3140 avi työaika網頁CANCER STEM CELLS CSCs refer to a subset of tumor cells that have an unlimited self-renewal capacity and an intense tumorigenic potential (stemness) to differentiate into their non-tumorigenic progenies which comprise the rest of the tumor bulk [13,14].Among ... avi työsuojelu oulu